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. 2018 Apr 13;9(28):19688–19703. doi: 10.18632/oncotarget.24802

Figure 1. Human APP expression and processing in transgenic mice with or without PLTP deficiency.

Figure 1

(A–C) Soluble forms of amyloid-beta 1–40, amyloid-beta 1–42, and oligomeric amyloid-beta 1–42 were assayed in hemibrain homogenates from 6 months old TgAPP mice (n = 8) and TgAPP/PLTP–/– mice (n = 7) using ELISA kits, and results were normalized to protein concentrations. (D–E) Expression of the human APP transgene and of the APP-cleaving enzyme BACE1 was determined in hemibrain homogenates from TgAPP mice (n = 8) and TgAPP/PLTP–/– mice (n = 7) by Western Blot and normalized to the expression of the loading control beta-tubulin. Results are presented as mean ± SEM.