Table 2. ROC analysis of exosomal miRNA in liquid biopsies.
| Groups Compared | miRNA | Cut Point | Sensitivity | Specificity | Correctly Classified | AUC |
|---|---|---|---|---|---|---|
| SCLC vs. Control | hsa-miR-1180 | ( ≥.0000.. ) | 80.00% | 90.00% | 86.67% | 0.94 |
| hsa-miR-451a | ( ≥.0047.. ) | 83.33% | 100.00% | 93.75% | 0.98 | |
| hsa-miR-486-5p | ( ≥.0038.. ) | 100.00% | 90.00% | 93.75% | 0.98 | |
| hsa-miR-363-3p | ( ≥.000089 ) | 83.33% | 100.00% | 93.75% | 0.95 | |
| NSCLC vs. Control | hsa-miR-660-5p | ( ≥ 8.87e.. ) | 83.33% | 100.00% | 93.75% | 0.91 |
| hsa-miR-15b-5p | ( ≥.000015 ) | 83.33% | 90.00% | 87.50% | 0.91 | |
| hsa-miR-25-3p | ( ≥.000109 ) | 83.33% | 90.00% | 87.50% | 0.91 | |
| hsa-miR-16-2-3p | ( ≥ 6.05e.. ) | 83.33% | 100.00% | 93.75% | 0.88 | |
| hsa-miR-221-3p | ( ≥.0014.. ) | 100.00% | 80.00% | 88.89% | 0.95 | |
| SCLC Treated vs. Untreated | hsa-miR-224-5p | ( ≥ 6.86e.. ) | 100.00% | 80.00% | 88.89% | 0.9 |
| hsa-miR-125b-5p | ( ≥.000045 ) | 60.00% | 100.00% | 77.78% | 0.8 | |
| hsa-miR-1228-5p | ( ≥ 3.56e.. ) | 80.00% | 100.00% | 90.91% | 0.9333 | |
| hsa-miR-1246 | ( ≥.0008.. ) | 60.00% | 100.00% | 81.82% | 0.8333 | |
| hsa-miR-203 | ( ≥.000022 ) | 80.00% | 100.00% | 90.91% | 0.8333 | |
| hsa-miR-483-5p | ( ≥.0000.. ) | 80.00% | 100.00% | 90.91% | 0.8333 | |
| hsa-miR-542-3p | ( ≥ 3.82e.. ) | 83.33% | 80.00% | 81.82% | 0.8 | |
| hsa-miR-331-5p | ( ≥ 4.67e.. ) | 100.00% | 100.00% | 100.00% | 1 | |
| SCLC vs. NSCLC | hsa-miR-451a | ( ≥.0027.. ) | 100.00% | 100.00% | 100.00% | 1 |
| hsa-miR-486-5p | ( ≥.0076.. ) | 83.33% | 100.00% | 90.91% | 0.9667 | |
| hsa-miR-660-5p | ( ≥ 8.87e.. ) | 83.33% | 100.00% | 90.91% | 0.8667 | |
| hsa-miR-15b-5p | ( ≥.0000.. ) | 83.33% | 100.00% | 90.91% | 0.9333 | |
| hsa-miR-16-2-3p | ( ≥.0000.. ) | 66.67% | 100.00% | 81.82% | 0.8333 | |
| hsa-miR-25-3p | ( ≥.0002.. ) | 66.67% | 100.00% | 81.82% | 0.8667 | |
| hsa-miR-363-3p | ( ≥.0000.. ) | 100.00% | 100.00% | 100.00% | 1 |
* miRNA with area under curve (AUC) >0.80 were selected.