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. 2018 Apr 13;9(28):19793–19806. doi: 10.18632/oncotarget.24857

Table 4. The results of Molecular Activity Prediction algorithm (IPA) predicting the effect of miRNA on the expression levels of genes in NSCLC and SCLC tissues.

Group Effector Molecules Predicted Effect
NSCLC TP63 ↑ CCND1 ↓ EPHA2 ↑
EGFR ↓ IGF1R ↓ Integrin ↓ FAK ↓
ITGA5 ↓ IGF1R ↓ ABL1 ↑ PXN ↓
EGFR ↓ JUN ↓ F2 ↓ P38MAPK ↑ MET ↓
RON (MST1R) (.)
SCLC IKZF1 ↓ AXL ↑
EGFR ↓ EPHA2 (.)
MET ↓ EGFR ↓ FAK ↓
NRP1 ↓ PXN ↓
F2 ↓ EGFR ↓ ITGB4 ↓ NRP1 ↓ P38MAPK ↓ MET ↓
ESR1 ↓ RON (MST1R) ↑
AXL (.)
SCLC Treated TP53 ↓ EPHA2 ↓
ERBB2 ↓ IGF1R ↓ MYCN ↓ FAK ↓
IGF1R ↓ CCR5 ↓ ABL1 ↓ PXN ↓
FOS ↑ P38MAPK ↓ MET ↑
ESR1 ↑ RON (MST1R) ↓
ERBB2 ↓ AXL ↓

↑- upregulation, ↓-downregulation, (.) - no effect.