Table 4. The results of Molecular Activity Prediction algorithm (IPA) predicting the effect of miRNA on the expression levels of genes in NSCLC and SCLC tissues.
Group | Effector Molecules | Predicted Effect |
---|---|---|
NSCLC | TP63 ↑ CCND1 ↓ | EPHA2 ↑ |
EGFR ↓ IGF1R ↓ Integrin ↓ | FAK ↓ | |
ITGA5 ↓ IGF1R ↓ ABL1 ↑ | PXN ↓ | |
EGFR ↓ JUN ↓ F2 ↓ P38MAPK ↑ | MET ↓ | |
RON (MST1R) (.) | ||
SCLC | IKZF1 ↓ | AXL ↑ |
EGFR ↓ | EPHA2 (.) | |
MET ↓ EGFR ↓ | FAK ↓ | |
NRP1 ↓ | PXN ↓ | |
F2 ↓ EGFR ↓ ITGB4 ↓ NRP1 ↓ P38MAPK ↓ | MET ↓ | |
ESR1 ↓ | RON (MST1R) ↑ | |
AXL (.) | ||
SCLC Treated | TP53 ↓ | EPHA2 ↓ |
ERBB2 ↓ IGF1R ↓ MYCN ↓ | FAK ↓ | |
IGF1R ↓ CCR5 ↓ ABL1 ↓ | PXN ↓ | |
FOS ↑ P38MAPK ↓ | MET ↑ | |
ESR1 ↑ | RON (MST1R) ↓ | |
ERBB2 ↓ | AXL ↓ |
↑- upregulation, ↓-downregulation, (.) - no effect.