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Ceramide is generated from the major pathways such as the de novo pathway, the salvage pathway and the sphingomyelin pathway. Ceramide can be phosphorylated to ceramide-1-phosphate (C1P), broken down to sphingosine and phosphorylated to sphingosine-1-phosphate (S1P). The gene expression of ceramide metabolism in The Cancer Genome Atlas (TCGA) cohort (n=112) were analyzed.
