Table 5. Analysis of prognostic factors for survival in eCCA using Cox proportional hazard modeling.

			Survival (%)		Univariate	Multivariate
		n	3-year	5-year	P	Hazard ratio (95%CI)	P
Sex	Male	93	42	31	0.49
	Female	24	33	17
Age, years	<71	58	39	25	0.57
	≥71	59	42	32
Tumor size, cm	<3	88	42	32	0.10
	≥3	29	36	18
Location	Perihilar	70	49	31	0.13
	Distal	47	28	24
Histopathological classification	pap + well	34	62	41	0.32	1.07 (0.66–1.78)	0.78
	mod + por	83	32	24
Invasion to hepatic artery	Negative	112	42	30	0.89
	Positive	5	20	20
Invasion to portal vein	Negative	93	44	32	0.14
	Positive	24	29	13
Lymphatic vessel invasion	Negative	35	51	31	0.57
	Positive	82	36	27
Venous invasion	Negative	42	57	43	0.024	1.49 (0.94–2.39)	0.087
	Positive	75	31	20
Perineural invasion	Negative	15	47	27	0.49
	Positive	102	40	29
pT	1 + 2	63	49	36	0.031	1.50 (0.96–2.33)	0.076
	3 + 4	54	30	19
pN	0	63	54	38	0.001	1.49 (0.93–2.38)	0.099
	1	54	25	17
pM	0	115	42	30	0.001	4.62 (0.66–20.0)	0.11
	1	2	0	0
Infiltration of CD4+ T lymphocytes	Low	30	14	14	0.009	0.61 (0.38–1.00)	0.049
	High	87	49	33
Infiltration of CD8+ T lymphocytes	Low	45	30	21	0.18
	High	72	47	33
Infiltration of Foxp3+ lymphocytes	Low	112	42	30	0.10
	High	5	0	0
PD-L1 expression	Low	107	45	32	<0.001	4.27 (1.82–9.39)	0.001
	High	10	0	0
E-cadherin expression	Low	58	32	19	0.033	0.71 (0.45–1.12)	0.14
	High	59	49	37
N-cadherin expression	Low	97	47	32	0.002	2.20 (1.18–3.92)	0.015
	High	20	10	10
Vimentin expression	Low	108	44	31	0.024	0.80 (0.30–1.93)	0.63
	High	9	11	11