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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Thromb Res. 2018 Apr;164(Suppl 1):S130–S135. doi: 10.1016/j.thromres.2018.01.005

Figure 2. Reduction/Oxidation Mechanism of Protein Disulfide Isomerase.

Figure 2

Shown is a reaction scheme diagramming the PDI active site transitioning between a reduced (left) and oxidized (right) state performing disulfide bond reduction (left to right) or oxidation (right to left) on a protein substrate. PDI active site (lower) and protein substrate (upper) are shown. Modified from (8)