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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Thromb Res. 2018 Apr;164(Suppl 1):S130–S135. doi: 10.1016/j.thromres.2018.01.005

Figure 3. Inhibition of PDI with isoquercetin decreases thrombin-induced thrombin generation through FVa.

Figure 3

Diagram of the proposed role of PDI in the activation of platelet factor V and the downstream generation of thrombin in the absence (Panel A) and presence (Panel B) of isoquercetin (9) MMN1: Multimerin-1; FV: Platelet Factor V; IIa: Thrombin; FVa: Factor Va; Xa: Factor Xa; II: Prothrombin; IQ: Isoquercetin; a-b-b’-a’: PDI.