Table 2.

Diagnostic accuracy of high baseline nitrite and ADMA levels and low baseline l-arginine level and l-arginine/ADMA ratio in predicting 28-day mortality in patients with necrotizing soft tissue infection

	Nitrite	l-Arginine	ADMA	l-Arginine/ADMA
Sensitivity	0.50 (0.31–0.69)	0.58 (0.39–0.76)	0.63 (0.42–0.80)	0.71 (0.51–0.86)
Specificity	0.50 (0.46–0.54)	0.52 (0.48–0.56)	0.53 (0.48–0.56)	0.54 (0.50–0.58)
PPV	0.18 (0.11–0.25)	0.20 (0.13–0.27)	0.22 (0.15–0.28)	0.25 (0.18–0.30)
NPV	0.82 (0.75–0.89)	0.86 (0.79–0.92)	0.87 (0.80–0.93)	0.90 (0.83–0.95)
Area under ROC curve	0.48 (0.34–0.62)	0.52 (0.38–0.65)	0.63 (0.51–0.75)	0.63 (0.53–0.73)

ADMA indicates asymmetric dimethylarginine; NPV, negative predictive value; PPV, positive predictive value. Data are presented as fractions (95% CI). The prevalence of 28-day mortality was 17%. High and low baseline levels were defined by the median.