Table 4.

Univariate and multivariate logistic regression analyses of mortality up to day 28 (time of censoring) in patients with necrotizing soft tissue infection based on high versus low concentrations of the biomarkers according to the optimal cutoff

	Unadjusted			Adjusted for age, sex, chronic disease			Adjusted for sex, chronic disease, SAPS II*
	OR	95% CI	P	OR	95% CI	P	OR	95% CI	P
Nitrite
Low (≤1.49 μmol/L)	1			1			1
High (>1.49 μmol/L)	2.20	0.62–7.85	0.22	1.87	0.50–6.93	0.35	4.60	0.92–23.03	0.06
l-Arginine
High (>71.98 μmol/L)	1			1			1
Low (≤71.98 μmol/L)	0.59	0.23–1.54	0.28	0.56	0.21–1.48	0.24	0.61	0.18–2.06	0.43
ADMA
Low (≤0.40 μmol/L)	1			1			1
High (>0.40 μmol/L)	11.5	1.50–88.41	0.02	10.23	1.32–79.38	0.03	13.17	0.91–191	0.06
l-Arginine/ADMA ratio
High (>101.59)	1			1			1
Low (≤101.59)	5.76	1.85–17.90	0.003	5.02	1.59–15.91	0.006	6.03	1.41–25.84	0.016

^*Five patients were not included in the analysis due to missing data of SAPS II (one of whom died the first day of admission). When the missing variables were replaced with the minimal value and maximum value, the median SAPS II was 27 (18–44) and 37 (30–54), respectively. Age is included in SAPS II. Optimal cutoff was found by the maximum sum of sensitivity and specificity.

ADMA indicates asymmetric dimethylarginine; CI, confidence interval; OR, odds ratio; SAPS II, Simplified Acute Physiology Score II.