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. 2018 May 1;13(5):e0196681. doi: 10.1371/journal.pone.0196681

Fig 1. Flowchart detailing the construction of an individual-specific miRNA-lncRNA network (ISMLN).

Fig 1

(A) Construction of the reference miRNA-lncRNA network. After selecting n non-tumor samples as the reference samples and 155653 miRNA-lncRNA associations as the basic edges, the reference network is constructed by computing the Pearson Correlation Coefficients (PCCs) based on miRNA and lncRNA expression data. (B) After the addition of the n+1th sample, which is a tumor sample, to the reference network, a perturbed miRNA-lncRNA network is built by calculating the PCCs. The difference between the above two miRNA-lncRNA networks is regarded as the individual-specific miRNA-lncRNA network (ISMLN).