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. 2018 May 1;13(5):e0196681. doi: 10.1371/journal.pone.0196681

Fig 2. The BMLN for each type of cancer.

Fig 2

Taking BRCA as an example, we obtained 508 ISMLNs. We then counted the number of samples with significant changes for each miRNA-lncRNA pair and calculated the significance score. For example, the miR-200a-XIST interaction was significantly altered in all 508 samples, so the corresponding significance score was 508/508 = 1. Similarly, the significance scores of all 155653 miRNA-lncRNA pairs were calculated. We then ranked the miRNA-lncRNA pairs in descending order based on their significance scores. Finally, we chose only the miRNA-lncRNA interactions with high scores for further analysis.