Table 2. NCCN criteria for referral for genetic risk evaluation for high-risk syndromes associated with CRC ^a .

1. Individuals meeting the Revised Bethesda Guidelines

2. Individuals meeting the Amsterdam Criteria

3. Individuals with >20 colorectal adenomas

4. Individuals with multiple gastrointestinal hamartomatous polyps or serrated polyposis

5. Individuals from a family with a known hereditary syndrome associated with CRC with or without a known mutation

6. Individuals with desmoid tumor, cribriform morular variant of papillary thyroid cancer, or hepatoblastoma

Abbreviation: CRC, colorectal cancer.

^a NCCN Clinical Practice Guidelines in Oncology Version 2.2015, nccn.org. ²¹