Table 5:

Allergic reactions induced by nonsteroidal anti-inflammatory drugs⁴⁷

Pathophysiology	Reaction type	Underlying condition	Symptoms
COX-1 inhibition (nonimmune)	NERD	Asthma, rhinitis, sinusitis, polyps	Upper and lower respiratory
	NECD	Chronic urticaria	Cutaneous
	NIUA	–	Cutaneous
IgE-mediated (immune-mediated)	SNIUAA	–	Cutaneous or anaphylaxis

Note: COX-1 = cyclooxygenase-1, IgE = immunoglobulin E, NECD = NSAID-exacerbated cutaneous disease, NERD = NSAID-exacerbated respiratory disease, NIUA = NSAID-induced urticaria/angioedema, NSAID = nonsteroidal anti-inflammatory drug, SNIUAA = single-NSAID–induced urticaria/angioedema or anaphylaxis.