Figure 2.

Dynamical Regimes of the AC-DC Circuit

(A) Stability diagram showing the available steady states of each gene for different values of the signal S using the parameters of Table S1. Thick solid lines show stable steady states, dashed lines show unstable states. Shaded areas show the range of expression of oscillatory states, which are delimited by thin solid lines. The bifurcation diagram was obtained using integration and continuation techniques (Clewley, 2012). See also Figure S1.

(B) Expression of gene X in time for different signal levels exhibiting three different dynamical regions. Initial condition is X = 0, Y = 0, Z = 0.