Table 2.
The top 10 enriched GO terms of the down‐regulated genes
| Category | GO ID and term | Count | P | Genes |
|---|---|---|---|---|
| Cellular component ontology | 0005576: extracellular region | 14 | 1.73 × 10−5 | CXCL1, HIST1H4K, PGF, C3, CXCL2, CAPZA1, CXCL8, CTSS, C1S, LAMA4, GLIPR1, EBI3, WFDC3, ANGPTL4 |
| 0005615: extracellular space | 10 | 0.001789369 | CXCL1, C3, PGF, CXCL2, CXCL8, STC1, CTSS, EBI3, SCG2, ANGPTL4 | |
| 0043234: protein complex | 5 | 0.011342677 | HIST1H4K, PTGS2, SMARCE1, PDGFRA, STRA6 | |
| 0016020: membrane | 10 | 0.039396582 | SLC16A3, FOS, GCNT2, HIST1H4K, PGF, GLIPR1, ARFRP1, PDGFRA, METTL7A, IL3RA | |
| 0072562: blood microparticle | 3 | 0.041879351 | C3, C1S, ANGPTL4 | |
| Biological process ontology | 0006954: inflammatory response | 7 | 2.21 × 10−4 | CXCL1, FOS, PTGS2, C3, CXCL2, CXCL8, SCG2 |
| 0006955: immune response | 7 | 3.88 × 10−4 | CXCL1, C3, CXCL2, RFX1, CXCL8, CTSS, IFI6 | |
| 0050930: induction of positive chemotaxis | 3 | 5.41 × 10−4 | PGF, CXCL8, SCG2 | |
| 0090023: positive regulation of neutrophil chemotaxis | 3 | 0.001179039 | CXCL1, CXCL2, CXCL8 | |
| 0001525: angiogenesis | 5 | 0.00172978 | PTGS2, PGF, CXCL8, SCG2, ANGPTL4 | |
| 0045766: positive regulation of angiogenesis | 4 | 0.002389639 | C3, PGF, CXCL8, ANGPTL4 | |
| 0032496: response to lipopolysaccharide | 4 | 0.006460182 | CXCL1, FOS, PTGS2, CXCL2 | |
| 0060326: cell chemotaxis | 3 | 0.009969718 | CXCL1, CXCL2, PDGFRA | |
| 0070098: chemokine‐mediated signaling pathway | 3 | 0.011807301 | CXCL1, CXCL2, CXCL8 | |
| 0008285: negative regulation of cell proliferation | 5 | 0.013070326 | CXCL1, RARRES3, NDN, PTGS2, CXCL8 | |
| Molecular function ontology | 0008009: chemokine activity | 3 | 0.005428355 | CXCL1, CXCL2, CXCL8 |
| 0045236: CXCR chemokine receptor binding | 2 | 0.020082714 | CXCL1, CXCL2 | |
| 0000978: RNA polymerase II core promoter proximal region sequence‐specific DNA binding | 4 | 0.045260858 | FOS, NDN, SMARCE1, RFX1 |