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. Author manuscript; available in PMC: 2018 Oct 9.
Published in final edited form as: Cancer Cell. 2017 Sep 28;32(4):411–426.e11. doi: 10.1016/j.ccell.2017.08.018

Figure 3. PRMT5 inhibition promotes G2/M arrest and senescence.

Figure 3

(A) Immunoblot of SDMA over time for U-87 MG cells treated with 10 µM EPZ. (B) Relative proliferation of indicated GBM cell lines in response to DMSO control or 10 µM EPZ. Significance estimated by unpaired t-tests. (C, D) FACS-based cell cycle profiles (C, left) with quantification (C, right) and senescence-associated (SA) β-galactosidase staining (D) of U-87 MG cells treated with DMSO or 10 µM EPZ. Significance estimated by unpaired t-test. Error bars = +/− SEM. See also Figure S3.