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. Author manuscript; available in PMC: 2019 May 10.
Published in final edited form as: Eur J Med Chem. 2018 Apr 12;151:777–796. doi: 10.1016/j.ejmech.2018.04.024

Scheme 7.

Scheme 7

Synthesis of compounds 70–72.

Reagents and conditions: (a) ethyl 3-aminocrotonate, Mn(OAc)3, MeCN, reflux. (b) i) THF, AcONa, ethyl acetoacetate, reflux; ii) EtOH, MeNH2/H2O, reflux.