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. Author manuscript; available in PMC: 2019 May 10.
Published in final edited form as: Eur J Med Chem. 2018 Apr 12;151:777–796. doi: 10.1016/j.ejmech.2018.04.024

Scheme 8.

Scheme 8

Synthesis of compounds 73–76.

Reagents and conditions: (a) MeCN, K2CO3, ethyl nitroacetate, reflux. (b) AcOH, Mn(OAc)3, ethyl nitroacetate, 70 °C. (c) ethyl diazoacetate, toluene, reflux.