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. Author manuscript; available in PMC: 2019 May 10.
Published in final edited form as: Eur J Med Chem. 2018 Apr 12;151:777–796. doi: 10.1016/j.ejmech.2018.04.024

Figure 2.

Figure 2

(A) Schematic representation of TDP2 and TDP1-catalyzed phosphotyrosyl cleavage reaction. Representative inhibition gels of compound 1 against Rec TDP2 (B), TDP2 WCE (C) and TDP1 (D). (E) Dose-response curves of 1 against Rec TDP2 and TDP2 WCE expressed as mean ± SD. Testing concentrations: 0.46, 1.4, 4.1, 12.3, 37 and 111 μM.