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. Author manuscript; available in PMC: 2019 May 10.
Published in final edited form as: Eur J Med Chem. 2018 Apr 12;151:777–796. doi: 10.1016/j.ejmech.2018.04.024

Scheme 2.

Scheme 2

Synthesis of compounds 8–55.

Reagents and conditions: (a) 2N Na2CO3, i-PrOH, reflux. (b) i) chloroform, SOCl2, reflux; ii) DMAP, TEA, amines for 8–12 or alcohols for 13–55.