Table 3.
The inhibitory activity of synthesized compounds against TDP2.
| Cpd. | IC50 (μM)a | Cpd. | IC50 (μM)a | ||
|---|---|---|---|---|---|
|
|
|
||||
| TDP2 | TDP2 WCE | TDP2 | TDP2 WCE | ||
| 56 | 32 ± 1.6 | 24 ± 5.3 | 67 | >111 | ND |
| 57 | 43 ± 17 | 38 ± 8.2 | 68 | >111 | ND |
| 58 | >111 | NDb | 69 | 29 ± 7.4 | 39 ± 4.1 |
| 59 | 16 ± 2.0 | 12 ± 2.1 | 70 | >111 | ND |
| 60 | 19 ± 5.7 | ND | 72 | >111 | ND |
| 61 | 66 ± 11 | 72 ± 18 | 73 | 3.3 ± 0.43 | 3.1 ± 0.1 |
| 62 | 20 ± 1.1 | 16 ± 2.2 | 74 | 1.9 ± 0.28 | 2.1 ± 0.1 |
| 63 | 8.1 ± 0.11 | 8.3 ± 2.0 | 75 | >111 | ND |
| 64 | 22 ± 2.0 | 13 ± 0.03 | 76 | >111 | ND |
| 65 | 50 ± 11 | 28 ± 7.1 | 77 | >111 | ND |
a
The IC50 was expressed as mean ± SD from at least three independent experiments unless otherwise indicated.
b
“ND” means “not determined”.