Table 3.
Clinical variables predicting the development of dnDSA at 24 months.
| Variables predicting dnDSA | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| OR | CI 95% | p value | OR | CI 95% | p value | |
| Post-transplant d-sp IFN-γ ELISPOT (NEG) | 0.128 | 0.015-0.99 | 0.049 | 0.085 | 0.008-0.862 | 0.037 |
| Induction type rATG (no) | 0.356 | 0.077-1.642 | 0.192 | 0.154 | 0.023-1.005 | 0.051 |
| Clinical BPAR (no) | 0.413 | 0.074-2.303 | 0.314 | 0.430 | 0.046-4.062 | 0.462 |
| 6-month sc-TCMR | 0.456 | 0.082-2.524 | 0.372 | 1.126 | 0.145-8.743 | 0.916 |
| DGF | 0.765 | 0.171-3.427 | 0.739 | 0.913 | 0.173-4.823 | 0.918 |
| HLA mismatch | 1.387 | 0.693-2.775 | 0.366 | |||
| Eplet HLA AB mismatch | 1.055 | 0.931-1.195 | 0.404 | |||
| Eplet HLA DRB1 and DQA/B mismatch | 1.013 | 0.951-1.079 | 0.688 | |||
| Donor Age | 0.994 | 0.947-1.043 | 0.798 | |||
| Donor type (L/D) | 1.200 | 0.227-6.334 | 0.831 | |||
| Time HD (months) | 1.002 | 0.981-1.024 | 0.854 | |||
BPAR, biopsy proved acute rejection; D, deceased; DGF, delayed graft function; dnDSA, de novo donor-specific antibodies; HD, hemodialysis; L, living; NEG, negative ELISPOT; rATG, rabbit anti-thymoglobulin. Data is presented as Mean±SD. ‘p’ values for binary logistic regression.