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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Trends Cancer. 2018 Mar 13;4(4):292–319. doi: 10.1016/j.trecan.2018.02.005

Figure 2. Chronology of measurements of physical parameters in tumors and evolution of mathematical models in our research.

Figure 2

(A) Timeline of first measurements of physical and physiological parameters of tumors, their relation to drug delivery in tumors, and strategies to reengineer the tumor microenvironment to improve therapy. (B) Timeline of the evolution of mathematical models throughout our research. Symbols: [a]= [18, 19, 72, 113, 200], [b]=[5, 104, 204], [c]= [14, 33, 146, 201–203], [d]= [131, 206–211], [e]=[9, 32, 42], [f]=[12, 55], [g]= [109, 162, 172], [h]= [82, 109, 110, 123, 124], [i]=[162, 213].