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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Trends Cancer. 2018 Mar 13;4(4):292–319. doi: 10.1016/j.trecan.2018.02.005

Figure 3. Solid mechanics of cancer.

Figure 3

(A) Experimental measurements of solid stress from the center towards the tumor periphery. Stress is compressive in at the interior of the tumor, whereas at the periphery becomes tensile. (B) Data showing that solid stress increases as a function of the tumor volume with a lack of increase in matrix stiffness. (C) Tumor mechanical properties between the primary tumor and metastasis are similar in AK4.4 and SL4 tumors but solid stress can differ. (Panels A – C reproduced with permission from [36]). (D) Residual stress is quantifying by the tumor opening, which is the opening that it is formed when a tumor is excised and partially cut along the long axis. Residual stress is evident in all murine and human tumors tested. To account for variations in tumor size, tumor opening is normalized by division with the tumor diameter. (Reproduced with permission from [9]).