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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Trends Cancer. 2018 Mar 13;4(4):292–319. doi: 10.1016/j.trecan.2018.02.005

Figure 4. Causes, consequences and remedies for solid stress in tumors.

Figure 4

(A) Histological data of human tumors show the position of cancer cells (red arrows) and the compression or collapse of blood vessels. Scale bar: 100 µm (reproduced with permission from [12]). (B) Selective depletion of cancer cells, CAFs, collagen or hyaluronan can decrease tumor opening and thus, alleviate solid stress (reproduced with permission from [9]). (C) Tumor perfusion decreases with an increase in tumor volume, presumably owing to accumulation of solid stress (reproduced with permission from [36]).