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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Ann Pharmacother. 2018 Jan 24;52(6):513–521. doi: 10.1177/1060028017753480

Figure 3.

Figure 3

Next-day probability of delirium versus same-day cumulative dose of fentanyl in critically ill patients: The solid black line represents the nonlinear relationship between the future (ie, next day) probability of delirium (vs nondelirious) with the cumulative same-day dose of fentanyl in micrograms, adjusted for the mode/median of other covariates in the single multivariable logistic regression model. Covariates for our single model included fentanyl dose and mental status (eg, normal, coma, or delirium), same-day plasma dexmedetomidine concentration, and same day of lorazepam concentration analysis (see also Figures 1 and 2). The gray area represents the 95% CI for this relationship. The number of evaluable patients was 62, given that persistently comatose and missing exposure/outcomes were disallowed.