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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: J Mol Neurosci. 2018 Mar 12;64(4):523–532. doi: 10.1007/s12031-018-1053-y

Figure 1. Time-dependent effects of scopolamine on SFK Y416 phosphorylation in the rat CPu.

Figure 1

(A) Effects of scopolamine on phosphorylation of SFK Y416 and expression of Fyn and Src. Rats were administered with scopolamine (5 mg/kg, i.p.) and were sacrificed at a different time point (7.5, 15, or 30 min) after scopolamine injection. (B) Effects of saline and scopolamine on phosphorylation of SFK Y416 and expression of Fyn and Src. Rats were administered with saline (Sal) or scopolamine (Sco, 5 mg/kg, i.p.) and were sacrificed 1 or 3 h after saline or scopolamine injection. Representative immunoblots are shown to the left of the quantified data. Note that scopolamine induced a time-dependent increase in Y416 phosphorylation, while the antagonist did not alter expression of total Fyn and Src proteins. Data are presented as means ± SEM (n = 3–5 per group). *P < 0.05 versus saline (0 min) (A) or saline at the same time point (B).