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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: J Mol Neurosci. 2018 Mar 12;64(4):523–532. doi: 10.1007/s12031-018-1053-y

Figure 3. Effects of coadministration of SKF81297 and scopolamine on SFK Y416 phosphorylation in the rat striatum.

Figure 3

(A) Effects of coadministration of SKF81297 and scopolamine on phosphorylation of SFK Y416 and expression of Fyn and Src in the CPu. (B) Effects of coadministration of SKF81297 and scopolamine on phosphorylation of SFK Y416 and expression of Fyn and Src in the NAc. Representative immunoblots are shown to the left of the quantified data. Note that SKF81297 and scopolamine when coadministered induced a marked increase in pY416 levels in both the CPu and NAc, while the two agents injected alone had no effect. Rats were administered with SKF81297 (SKF, 1 mg/kg, i.p.) or scopolamine (Sco, 1 mg/kg, i.p.) or the two agents together and were sacrificed 45 min after drug injection for Western blot analysis. Data are presented as means ± SEM (n = 4 per group). *P < 0.05 versus saline.