. Author manuscript; available in PMC: 2018 Jul 23.

Published in final edited form as: J Allergy Clin Immunol Pract. 2017 Oct 31;6(4):1287–1296.e1. doi: 10.1016/j.jaip.2017.09.004

Table 2.

Summary of cohort clinical characteristics, SCAR history and outcomes post testing

Study No.	Age-Sex	ICH^a		SCAR Phenotype	Culprit antibiotics(s)		Ex vivo or in vivo positive	Antibiotic use post testing
Study No.	Age-Sex	Status	Immunosuppression	SCAR Phenotype	Antibiotic(s)	Phenotypic Score^b	Ex vivo or in vivo positive	Antibiotic use post testing
S1	72F	N		DRESS	CEF, VAN	6	Yes	VAN, AMP, FLU
S2	20M	N		TEN	TEIC	4	Yes	FLU
					MER	4
					VAN	4
S3	43M	N		SJS	TMP-SMX^c	5	No	NIL
S4	48M	N		DRESS	TMP-SMX	4	No	DOX
S5	83M	Y	ITP/Prednisolone	SJS	CEF	4	No	MER, DOX, CIP, VAN
S5	83M	Y	ITP/Prednisolone	SJS	PIP-TAZ	3	No	MER, DOX, CIP, VAN
S6	38F	N		DRESS	PIP-TAZ, VAN	7	Yes	CEFU
S7	74M	N		DRESS	CEFZ, MER, PENG	5	Yes	PENV, FLU
S8	62M	Y	NHL	DRESS	PIP-TAZ	4	Yes	CEPH
S9	57M	Y	AML/chemotherapy	DRESS	VAN, PIP-TAZ, MER	6	Yes	PIP-TAZ, MER
S10	51F	N		DRESS	VANC, CEFZ	6	Yes	NIL
S11	59F	N		DRESS	AMP	4	Yes	NIL
S12	52F	N		DRESS	VAN, PIP-TAZ, ADF	4	Yes	ADF, MER
S13	53F	N		AGEP₁	MET	8	Yes	PENV
S13	53F	N		AGEP₂	VAN, CIP	8	Yes	PENV
S14	60M	Y	AML/chemotherapy	DRESS	VAN, PIP-TAZ	4	No	CIP
S15	58M	N		DRESS	VAN, CIP	6	Yes	PENV
S16	75M	Y	DRESS/Prednisolone	DRESS	VAN, PIP-TAZ	2	Yes	CEPH
S17	66M	Y	HCL	DRESS	TMP-SMX^c	4	Yes	NIL
S18	71M	N		DRESS	PIP-TAZ, AMP	2	Yes	AMP
S19	54F	N		SJS	VAN	4	Yes	PENG

Abbreviations: ICH, immunocompromised host; SCAR, Severe Cutaneous Adverse Drug Reaction; N, no; Y, yes; ITP, immune mediated thrombocytopenia; NHL, non-Hodgkin lymphoma; AML, acute myeloid leukemia; DRESS, drug reaction with eosinophilia and systemic symptoms; HCL, hairy cell leukemia; M, male; F, female; AMP, ampicillin; ADF, amoxicillin clavulanate; CEF, ceftriaxone; CEFZ, cefazolin, CEFU, cefuroxime; CEFT, ceftazidime; CEPH, cephalexin; CIP, ciprofloxacin; FLU, flucloxacillin; MER, meropenem; MET, metronidazole; PENG, benzylpenicillin; PENV, penicillin VK; PIP-TAZ, piperacillin-tazobactam; TEIC, teicoplanin; VAN, vancomycin; 4NO, 4-Nitro sulfamethoxazole; TMP, trimethoprim, SMX, sulfamethoxazole; TMP-SMX, trimethoprim-sulfamethoxazole; FLU, flucloxacillin; Nil, no antibiotics required; DOX, doxycycline

ICH: Transplant recipient, haematological or oncological malignancy (last 5 years), steroids > 10mg prednisolone equivalent per day, connective tissue or autoimmune condition. Immunosuppression was defined as that the patient was receiving at time of PBMC collection.

Phenotypic scores as per published guidelines for SJS/TEN (ALDEN), DRESS (RegiSCAR) and AGEP.

Patient S3 had ibuprofen implicated in causality, ALDEN score (3) was lower than that of TMP-SMX. Patient S18 had cladribine and allopurinol implicated, also with lower ALDEN scores (3) that TMP-SMX.