. Author manuscript; available in PMC: 2020 Jan 1.

Published in final edited form as: Mult Scler. 2017 Nov 7;25(1):55–62. doi: 10.1177/1352458517739136

Table 1.

Patient Demographics

	All Subjects	NON Subjects	ON Subjects	ON vs NON p value
Number of subjects	47	25 (53%)	22 (47%)	–
Age (SD), years	59 (6.4)	59 (6.2)	58.9 (6.8)	0.92^a
Female (%)	28 (59.6%)	13 (52%)	15 (68.2%)	0.37^b
MS duration (SD), years	30 (9.4)	27.28 (10.05)	32.59 (7.8)	0.048^a
Median EDSS {range}	6.0 {4.3–6.3}	5.0 {4–6}	6.0 {4.5–6.9}	0.12^c
LogMAR visual acuity	0.145 (0.263)	0.102 (0.260)	0.231 (0.252)	0.065^d
On disease modifying therapy	21 (45%)	12 (48%)	9 (41%)	0.77^b
Number of eyes with history ON (%)	32/94 (34%)	–	32/44 (72.7%)	–

Bold values indicate p <0.05.

Significance testing:

^a)

2-sample t-test on means;

^b)

Fisher’s exact test;

^c)

Wilcox test on medians;

^d)

mixed-model with repeated measures correction

EDSS=expanded disability status score; MS=multiple sclerosis; NON=no history of optic neuritis; ON=history of optic neuritis in at least one eye; SPMS=secondary progressive multiple sclerosis; SD=standard deviation.