Table 2.
Comparison of SD-OCT Measures in SPMS Eyes With and Without a History of Optic Neuritis at Baseline. All values reported with standard deviation.
| All Eyes (n=80) |
ON eyes (n=23, 29%) |
NON eyes | ON vs NON eyesc (p value) |
|
|---|---|---|---|---|
| Mean RNFL thickness, μm | 77.3 (10.3) | 74.0 (11.3) | 78.7 (9.6) | 0.012 |
| Temporal quadrant, μm | 48.6 (11.5) | 46.0 (13.4) | 49.6 (10.6) | 0.214 |
| Superior quadrant, μm | 95.5 (16.3) | 91.8 (19.0) | 97.0 (15.1) | 0.053 |
| Nasal quadrant, μm | 64.5 (10.5) | 63.0 (11.4) | 65.1 (10.2) | 0.385 |
| Inferior quadrant, μm | 100.6 (17.2) | 95.1 (18.2) | 102.8 (16.4) | 0.178 |
| Mean Macular GCIPL thickness, μm | 67.4 (9.0)a | 62.1 (10.2)b | 69.7 (7.4) | <0.001 |
Bold values indicate p < 0.05.
a
n=74, GCIPL all eyes
b
n=22, 30% GCIPL ON eyes
c
Linear Mixed Modeling used to account for age, sex, and disease duration. ON= history of optic neuritis; NON= no history of optic neuritis; μm =microns; GCIPL=ganglion cell plus inner plexiform layer.