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. 2018 Apr 25;11:133. doi: 10.3389/fnmol.2018.00133

FIGURE 1.

FIGURE 1

Effect of social isolation for 3 weeks on sucrose preference, open field and forced swim tests (FSTs) in absence of Wdr13 gene in mice. (A) Wdr13 expression showed increase (Mann–Whitney; p < 0.05) in the hippocampus of wild-type mice upon social isolation (n = 4). Data represented as ±SD. (B) Sucrose preference test (Cohort#1). After social isolation, both Wdr13-/0 and wild-type mice showed anhedonia [Two-way repeated ANOVA, effect of days on both genotype F(4,40) = 3.775; p = 0.0107| interaction F(4,40) = 0.47; p > 0.05| between genotypes F(1,40) = 0.017; p > 0.05|n = 6]. (C) Open field test (OFT) (Cohort#1). Wdr13-/0 mice showed significant decrease [individual t-test; p < 0.05|| Two-way repeated ANOVA, effect of stress on genotypes F(1,20) = 5.757; p = 0.0263| interaction F(1,20) = 0.4292; p > 0.05| between genotypes F(1,20) = 2.736; p > 0.05] in exploration of central area of open field after social isolation than the wild-type mice (n = 6). (D) FST (Cohort#1). Socially isolated Wdr13-/0 mice remained immobile for more time [individual t-test; p < 0.05|| Two-way repeated ANOVA, interaction F(1,20) = 5.467; p = 0.0299] than their wild-type mice counterparts (n = 6). Wdr13+/0, wild-type; Wdr13-/0, Wdr13 knockout mice SI, Social Isolation. ∗ denotes p < 0.05 and ∗∗ denotes p < 0.005.