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. 2018 Apr 25;11:133. doi: 10.3389/fnmol.2018.00133

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Copyright © 2018 Mitra, Sameer Kumar, Jyothi Lakshmi, Thakur and Kumar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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8plex ITRAQ based quantitative proteomics of pre-frontal cortex (PFC) from wild-type and Wdr13^-/0 mice with and without social isolation. (A) Heat map representing proteomics data from PFC of Wdr13^-/0 mice and wild-type mice before and after social isolation (1% FDR, at-least one unique peptide). (B) Table depicting changes in the proteome. Out of 1722 quantified proteins, there was a significant proportion of downregulated proteins in Wdr13^-/0 mice after social isolation as compared to wild-type (1.2-fold as upregulated and less than 0.83 as downregulated). (C) Relative levels of four synaptic proteins that showed downregulation in socially isolated Wdr13^-/0 mice than wild-type counterparts, while showed upregulation under normal conditions. It may be noted that levels of these proteins remained unchanged in socially isolated wild-type. Wdr13^+/0, wild-type; Wdr13^-/0, Wdr13 knockout mice; SI, Social Isolation.