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. 2018 Apr 25;11:133. doi: 10.3389/fnmol.2018.00133

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Copyright © 2018 Mitra, Sameer Kumar, Jyothi Lakshmi, Thakur and Kumar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression analysis of synaptic genes and histological examination of hippocampus in Wdr13^-/0 mice after 3 weeks social isolation. (A) Heat map of quantified proteins from hippocampus of socially isolated Wdr13^-/0 mice using iTRAQ based proteomics. (B) Transcript levels of synaptic genes like Nrxn2, Rab3a, Syn1 showed decrease in the Wdr13^-/0 hippocampus (t-test; p < 0.05) than the wild-type (n = 5). (C) (i) Representative images showing CA1 neurons in wild-type and Wdr13^-/0 mice after social isolation. (ii) Spine density of CA1 neurons in different groups (individual t-test; p < 0.05). (D) The dendritic branching of hippocampal CA1 neurons in Wdr13^-/0 mice was significantly lesser (Two-way ANOVA, F(1,3900) = 8806; p < 0.005) than the wild-type mice after social isolation. Wdr13^+/0, wild-type; Wdr13^-/0, Wdr13 knockout mice; SI, Social Isolation. ^∗ denotes p < 0.05 and ^∗∗ denotes p < 0.005.