Table 4.
Patient oriented eczema measure (POEM) scores during 16 week primary outcome period, by group and subgroup
| Repeated measures | No (%) | Mean (SD) | Interaction term (95% CI) | Adjusted difference in mean POEM score* (95% CI) | |
|---|---|---|---|---|---|
| Bath additives | No bath additives | ||||
| Age (years): | |||||
| <5 | 256 (53) | 6.99 (5.67) | 9.09 (6.01) | −1.43 (−2.02 to −0.15) | 1.29 (0.33 to 2.25) |
| ≥5 | 226 (47) | 7.97 (6.24) | 7.52 (5.92) | −0.29 (−1.21 to 0.63) | |
| Baseline eczema severity: | |||||
| Mild (0-7) | 187 (39) | 4.78 (4.26) | 5.22 (4.58) | −0.05 (−1.14 to 1.05) | −0.07 (−1.08 to 0.95) |
| Moderate (8-16) | 233 (48) | 8.14 (5.54) | 9.18 (5.46) | 0.65 (−0.45 to 1.74) | |
| Severe (17-28) | 62 (13) | 14.63 (6.16) | 13.03 (6.92) | −1.16 (−3.62 to 1.32) | |
| Use of leave-on emollient weekly: | |||||
| 0-4 days | 138 (29) | 7.64 (6.68) | 6.43 (5.42) | −0.02 (−2.05 to 2.01) | 0.26 (−1.34 to 1.86) |
| 5-7 days | 344 (71) | 8.61 (5.74) | 7.93 (6.14) | 0.69 (−0.39 to 1.76) | |
| Topical corticosteroid use: | |||||
| Any | 241 (51) | 8.40 (6.19) | 9.35 (6.21) | 0.52 (−1.35 to 2.40) | 1.22 (−0.18 to 2.63) |
| None | 234 (49) | 6.63 (5.64) | 7.39 (5.66) | 0.58 (−0.64 to 1.81) | |
| Frequency of bathing at 16 weeks: | |||||
| 1-4 times/week | 255 (64) | 7.93 (5.94) | 8.00 (5.82) | 2.14 (0.21 to 4.07) | −0.26 (−1.38 to 0.87) |
| ≥5 times/week | 143 (36) | 6.30 (5.70) | 8.75 (6.12) | 2.27 (0.63 to 3.91) | |
| Prior belief in bath additives: | |||||
| Low (1-3) | 106 (29) | 7.93 (6.10) | 9.27 (6.25) | 0.85 (−0.52 to 2.21) | 1.17 (−0.78 to 3.13) |
| Moderate (4-6) | 158 (44) | 8.37 (6.06) | 8.68 (6.02) | −0.16 (−1.77 to 1.45) | |
| High (7-9) | 97 (27) | 5.70 (5.06) | 7.09 (6.05) | 1.80 (0.04 to 3.56) | |
| Use of soap substitute at 16 weeks: | |||||
| Any | 89 (21) | 8.09 (6.10) | 9.31 (5.88) | 1.30 (−0.97 to 3.57) | 1.72 (−0.44 to 3.88) |
| None | 340 (79) | 7.17 (5.82) | 7.99 (5.87) | 0.36 (−0.63 to 1.35) | |
*
Adjusted for baseline severity, ethnic group, steroid use, and soap substitute use and allowing for clustering of patients within centres and responses within patients over time.