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. 2018 Apr 23;9:150. doi: 10.3389/fpsyt.2018.00150

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Copyright © 2018 Brancato, Castelli, Cavallaro, Lavanco, Plescia and Cannizzaro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Female rat alcohol drinking trajectories. Binge alcohol drinking (BAD) rats showed higher alcohol consumption than habitual alcohol drinking (HAD) rats during the last three pre-conceptional weeks, gestation and post-gestation. During gestation, BAD rats displayed a significant decrease in alcohol consumption with respect to the last three pre-gestational weeks. During post-partum days, drinking consumption of both groups increased with respect to gestational period, reproducing similar trajectories as recorded on pre-conceptional time. Each bar represents the mean ± SEM of n = 8 rats. ^∧p < 0.05, ^∧∧∧p < 0.001 vs. HAD rats; ^◦p < 0.05 within HAD group; ^•••p < 0.001 within BAD group.