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. 2018 Apr 23;9:150. doi: 10.3389/fpsyt.2018.00150

Figure 3.

Figure 3

Female rat pre-conceptional phenotype. Habitual (HAD) and binge (BAD) alcohol drinking patterns affect behavioral reactivity, anxiety-like behavior, reward sensitivity, and depression-like behavior. Open field test—(A) total distance traveled (TDT); (B) number of transitions in central areas (NTC); and (C) amount of time spent on the central areas of the arena (ATC). Elevated plus maze test—(D) percentage of time spent on the open arm; (E) percentage of entries in the open arm; (F) total entries. (G) Saccharin preference; (H) Forced swim test, where the parts-of-whole−10 × 10 dot—plots represent normalized mean values from immobility time (black); swimming time (gray); climbing time (white) in the three experimental groups. Each bar represents the mean ± SEM of n = 8 rats. Each box-and-whisker plot represents the median (horizontal line in the box), 25–75% (box) and min-to-max (whiskers) values of n = 8 rats. *p < 0.05, **p < 0.01; ***p < 0.001 vs. CTR rats; ∧∧∧p < 0.001 vs. HAD rats.