. Author manuscript; available in PMC: 2018 May 2.

Published in final edited form as: Int J Cancer. 2017 Apr 15;140(8):1727–1735. doi: 10.1002/ijc.30590

Table 2.

Odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) for pancreatic cancer risk according to H. pylori serology: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

	Control subjects	Case patients	Crude model¹		Adjusted model²

	N, %	N, %	OR	95% CI	OR	95% CI
H. pylori serology
Negative	241 (53.9)	250 (56.0)	1.00		1.00
Positive	206 (46.1)	196 (44.0)	0.91	0.68, 1.21	0.96	0.70, 1.31
CagA serology
Negative	306 (68.9)	302 (68.3)	1.00		1.00
Positive	138 (31.1)	140 (31.7)	1.02	0.76, 1.38	1.07	0.77, 1.48
H. pylori and CagA serology
H. pylori−, CagA−	214 (48.3)	218 (49.5)	1.00		1.00
H. pylori+ or CagA+	231 (51.9)	224 (50.7)	0.94	0.70, 1.25	0.99	0.73, 1.35
H. pylori−, CagA+	25 (5.6)	28 (6.4)	1.11	0.61, 2.02	1.14	0.59, 2.22
H. pylori+, CagA−	91 (20.5)	82 (18.6)	0.88	0.61, 1.27	0.94	0.63, 1.38
H. pylori+, CagA+	113 (25.5)	112 (25.4)	0.96	0.68, 1.37	1.04	0.63, 1.38
Sub-analysis stratified by ABO blood group (N=278, case-control pairs)
O blood group
H. pylori−, CagA−	59 (21.2)	49 (17.6)	1.00		1.00
H. pylori+ or CagA+	52 (18.7)	45 (16.2)	1.06	0.57, 1.96	1.17	0.60, 2.30
Non-O blood type
H. pylori−, CagA−,	76 (27.3)	86 (30.9)	1.00		1.00
H. pylori+ or CagA+	91 (32.7)	98 (35.3)	0.94	0.60, 1.46	0.86	0.54, 1.38

Crude conditional logistic regression model was inherently adjusted for the matching factors, including study center, sex, age at blood collection (±3 years), date of blood donation (±3 months), time of blood donation (±2 h), and fasting status (<3h, 3–6h or >6 after the last meal).

Adjusted conditional logistic regression model was inherently controlled for the matching factors, and was further adjusted for height, waist-to-hip ratio, smoking status (never, former or current) and diabetes mellitus status (no or yes).