FIG 7.

Schematic model of bile acid metabolism by bile acid 7α-dehydroxylating bacteria. (a) See introduction for information regarding the core bile acid 7α-dehydroxylation pathway catalyzed by bile acid-inducible (Bai) enzymes. Transport of oxo-bile acid derivatives hypothesized to import via sodium dependent-bile acid transporter (BaiG). See Table 1 for anaerobic culture-based bile acid conversion studies. (b) Alternative routes for conversion of 12-oxochenodeoxycholic acid (12-oxoCDCA) to 7-oxodeoxycholic acid (7-oxoDCA), observed in bile acid conversion experiments (Table 1).