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. Author manuscript; available in PMC: 2018 May 2.
Published in final edited form as: Oncogene. 2017 Jun 12;36(42):5771–5792. doi: 10.1038/onc.2017.189

Figure 4.

Figure 4

Mouse models of melanocytic nevi and melanoma. BrafV600E mutation in isolation results in the formation of small, growth-arrested nevi. When Pten in inactivated in the setting of Braf activation (Braf/Pten) no growth arrest is observed; rapid progression to metastatic melanoma ensues. When Cdkn2a is inactivated in the setting of Braf activation larger melanocytic nevi form, but are still stably growth arrested. With increasing age, a small proportion of nevi progress to melanoma at rates similar to human nevi. When Lkb1 is inactivated (constitutive mTORC1 activation) in the setting of Braf activation, growth arrest of nevi is abrogated, but melanoma never forms. When Dnmt3b is inactivated in the Braf/Pten model, most melanocytic lesions growth arrest, with rare progression to melanoma with advancing age.