Table II. Protein network analysis of upstream regulators of OAB.

Network	Upstream Regulators	Diseases & Functions	Identified Target Molecules
1	CR1L, complement component 3b/4b receptor 1-like	Cell movement of leukocytes	ALDOA, APOA1, BGN, C3, CD9, CNN1, COL18A1, COL1A1, COL4A1, CRYAB, DCN, FN1, GSN, HSPD1, ITGA5, ITGB1, LUM, MCAM, MYH11, MYL9, PFN1, SERPINA1, SERPINA3, SERPINE1, SERPINF1, Tpm2, YBX1
	HTT, huntingtin	Formation of epithelial tissue
	INHA, inhibin alpha	Muscle contraction
	ITGA2, integrin subunit alpha 2
2	CR1L, complement component 3b/4b receptor 1-like	Advanced stage solid tumor	COL18A1, COL4A1, COL6A3, FN1, NID2, SERPINE1
	SMAD7, SMAD family member 7	Metastatic solid tumor
3	HNF1B, HNF1 homeobox B	Cellular infiltration by leukocytes	APOA1, BGN, CRYAB, DCN, FGB, FN1, HSPD1, ITGB1, MCAM, SERPINA1, SPARC, YBX1
	HTT, huntingtin
	ITGA2, integrin subunit alpha 2
	PDGF (family), platelet derived growth factor
4	APP, amyloid beta precursor protein	Cell movement of sarcoma cell lines	CTSB, FN1, SERPINE1, SERPINF1, SOD2, STMN1, VCP
	NFE2L2, nuclear factor, erythroid 2 like 2
5	ANGPT2, angiopoietin 2	Anemia	ANXA1, APOE, C3, C4A/C4B, CFB, CP, CRP, FN1, HBB, LGALS3, PRDX1, PRDX2, PRDX3, RPS6, SOD1, SOD2, TF
	GH1, growth hormone 1
	Phenylbutazone
	Prednisolone
6	miR-122–5p (miRNAs w/seed GGAGUGU)	Carcinoma in lung	ALDOA, GPX7, P4HB, PKM, PRDX2, VIM
		Cell viability of tumor cell lines
7	HNF1B, HNF1 homeobox B	Cell movement of neutrophils	ALB, BGN, FGB, FN1, LUM, SERPINA1, SPARC
		Cellular infiltration by leukocytes
8	ANGPT2, angiopoietin 2	Endoplasmic reticulum stress response	CALR, DNAJB4, HSP90AB1, HSPA5, HSPD1, SERPINH1, SOD1
	Tanespimycin
9	INSR, insulin receptor	Proliferation of muscle cells	CTSB, FHL1, FN1, HSPD1, ITGA5, OGN, SERPINE1, VTN
	ITGAV, integrin subunit alpha V
10	Phenylbutazone	Anemia	ANXA1, ANXA2, C4A/C4B, CP, FGB, LGALS3
		Hemostasis