Table 2.

Multivariable linear regression (stepwise) showing significant clinical and psychological variables of total fatigue as measured with the MFI-20 in chronically critically ill patients (n = 113) 3 months following the discharge from ICU at acute care hospital. The final model was controlled for age and gender

Multivariable linear regressiona
	Beta	CI	p value
Clinical variables
Coronary heart disease	.27	.23–1.03	.002**
Psychological variables at (post-acute) ICU
Perceived fear of dying at ICU	.25	.08–.42	.005**
Psychological variables 3 months following ICU
Diagnosis of major depression according to SCID I	.26	.31–1.56	.004**
Perceived social support according to MSPSS	− .18	− .35–(−).01	.043*
R2 (corrected): .201 (F(4, 108) = 7.771, p < .001)

^aMethod stepwise; PTSD at t2 and perceived fear of dying at ICU were significantly correlated (point biserial coefficient = .242, p = .011); family status and MSPSS at t2 were significantly correlated (point biserial coefficient = − .264, p = .005). Number of medical comorbidities and diagnosis of major depression/coronary heart disease were significantly correlated (point biserial coefficient = .279, p = .003/.305, p = .001). For parsimony of the final model and to prevent multicollinearity, PTSD at t2, family status and number of medical diagnoses were not considered in the final model. Tolerance/variance inflation factor and condition number test did not indicate multicollinearity

MFI-20 Multidimensional Fatigue Inventory, MSPSS Multidimensional Scale of Perceived Social Support, PTSD posttraumatic stress disorder, SCID I Structured Clinical Interview according to DSM IV

*p ≤ .05, **p ≤ .01