Table 4.

List of miRNAs with therapeutic implications associated with lung cancer based on expression level, chromosome location, function, cancer mechanism and the corresponding target gene for therapy.

MiRNA	Expression	Location	Function	Cancer-Associated Mechanism	Target	References
miR-10b	increased	2q31.1	Oncogene	proliferation, metastasis	KLF4	[209-213]
miR-95	increased	4p16.1	Oncogene	radiosensitivity/ proliferation	SNX1	[198, 199]
miR-96	increased	7q32.2	Oncogene	cisplatin resistance/ apoptosis, invasion	SAMD9, FOXO3	[195-197]
miR-150	increased	19q13.33	Oncogene	proliferation, apoptosis	P53	[189, 190]
miR-196a	increased	17q21.32	Oncogene	cisplatin resistance/ proliferation/ invasion	HOXA5	[193, 194]
miR-205	increased	1q32.2	Oncogene	proliferation, apoptosis, carboplatin resistance	PTEN	[107-109, 183]
miR-221/222	increased	Xp11.3	Oncogene	migration, apoptosis, TRAIL resistance	PTEN, TIMP3	[176, 177]
miR-494	increased	14q32.31	Oncogene	apoptosis, TRAIL resistance	Bim	[178]
miR-873	increased	9p21.1	Oncogene	proliferation/ migration	SRCIN1	[191]
miR-26b	decreased	2q35	Tumor Suppressor	metastasis	MIEN1	[108, 206]
miR-34a	decreased	1p36.22	Tumor Suppressor	proliferation, apoptosis	TGFβR2, OCT4	[110, 186-188]
miR-124	decreased	8p23.1	Tumor Suppressor	proliferation, migration, invasion	SOX9	[172, 192]
miR-133a	decreased	18q11.2	Tumor Suppressor	growth, invasion, metastasis, proliferation, TRAIL resistance	IGF-1R, TGFBR1 and EGFR	[182]
miR-137	decreased	1p21.3	Tumor Suppressor	growth, invasion, TRAIL resistance	BMP7	[180]
miR-152	decreased	17q21.32	Tumor Suppressor	metastasis	NRP1	[208]
miR-187-3p	decreased	18q12.2	Tumor Suppressor	migration, invasion, apoptosis	BCL6	[201]
miR-200c	decreased	12p13.31	Tumor Suppressor	metastasis	ZEB2	[207]
miR-204	decreased	9q21.12	Tumor Suppressor	proliferation, migration, apoptosis	ATF2	[200]
miR-218	decreased	4p15.31	Tumor Suppressor	proliferation, apoptosis/ carboplatin resistance	PARP, Caspase 3, Bcl-2	[183]
miR-223	decreased	Xq12	Tumor Suppressor	chemoresistance, proliferation	IGF1R	[96, 185]
miR-326	decreased	11q13.4	Tumor Suppressor	apoptosis	CCND1	[202]
miR-329	decreased	14q32.31	Tumor Suppressor	proliferation, migration, invasion	MET	[205]
miR-377	decreased	14q32.31	Tumor Suppressor	proliferation, migration, invasion	AEG-1	[203]
miR-432	decreased	14q32.2	Tumor Suppressor	proliferation, cisplatin sensitivity	E2F3 and AXL	[184]
miR-449a	decreased	5q11.2	Tumor Suppressor	growth, invasion TRAIL resistance	MAP2K1	[181]
miR-455	decreased	9q32	Tumor Suppressor	proliferation, migration, invasion	ZEB1	[204]