Table 4.
MiRNA | Expression | Location | Function | Cancer-Associated Mechanism | Target | References |
---|---|---|---|---|---|---|
miR-10b | increased | 2q31.1 | Oncogene | proliferation, metastasis | KLF4 | [209-213] |
miR-95 | increased | 4p16.1 | Oncogene | radiosensitivity/ proliferation | SNX1 | [198, 199] |
miR-96 | increased | 7q32.2 | Oncogene | cisplatin resistance/ apoptosis, invasion | SAMD9, FOXO3 | [195-197] |
miR-150 | increased | 19q13.33 | Oncogene | proliferation, apoptosis | P53 | [189, 190] |
miR-196a | increased | 17q21.32 | Oncogene | cisplatin resistance/ proliferation/ invasion | HOXA5 | [193, 194] |
miR-205 | increased | 1q32.2 | Oncogene | proliferation, apoptosis, carboplatin resistance | PTEN | [107-109, 183] |
miR-221/222 | increased | Xp11.3 | Oncogene | migration, apoptosis, TRAIL resistance | PTEN, TIMP3 | [176, 177] |
miR-494 | increased | 14q32.31 | Oncogene | apoptosis, TRAIL resistance | Bim | [178] |
miR-873 | increased | 9p21.1 | Oncogene | proliferation/ migration | SRCIN1 | [191] |
miR-26b | decreased | 2q35 | Tumor Suppressor | metastasis | MIEN1 | [108, 206] |
miR-34a | decreased | 1p36.22 | Tumor Suppressor | proliferation, apoptosis | TGFβR2, OCT4 | [110, 186-188] |
miR-124 | decreased | 8p23.1 | Tumor Suppressor | proliferation, migration, invasion | SOX9 | [172, 192] |
miR-133a | decreased | 18q11.2 | Tumor Suppressor | growth, invasion, metastasis, proliferation, TRAIL resistance | IGF-1R, TGFBR1 and EGFR | [182] |
miR-137 | decreased | 1p21.3 | Tumor Suppressor | growth, invasion, TRAIL resistance |
BMP7 | [180] |
miR-152 | decreased | 17q21.32 | Tumor Suppressor | metastasis | NRP1 | [208] |
miR-187-3p | decreased | 18q12.2 | Tumor Suppressor | migration, invasion, apoptosis | BCL6 | [201] |
miR-200c | decreased | 12p13.31 | Tumor Suppressor | metastasis | ZEB2 | [207] |
miR-204 | decreased | 9q21.12 | Tumor Suppressor | proliferation, migration, apoptosis | ATF2 | [200] |
miR-218 | decreased | 4p15.31 | Tumor Suppressor | proliferation, apoptosis/ carboplatin resistance | PARP, Caspase 3, Bcl-2 | [183] |
miR-223 | decreased | Xq12 | Tumor Suppressor | chemoresistance, proliferation | IGF1R | [96, 185] |
miR-326 | decreased | 11q13.4 | Tumor Suppressor | apoptosis | CCND1 | [202] |
miR-329 | decreased | 14q32.31 | Tumor Suppressor | proliferation, migration, invasion | MET | [205] |
miR-377 | decreased | 14q32.31 | Tumor Suppressor | proliferation, migration, invasion | AEG-1 | [203] |
miR-432 | decreased | 14q32.2 | Tumor Suppressor | proliferation, cisplatin sensitivity | E2F3 and AXL | [184] |
miR-449a | decreased | 5q11.2 | Tumor Suppressor | growth, invasion TRAIL resistance |
MAP2K1 | [181] |
miR-455 | decreased | 9q32 | Tumor Suppressor | proliferation, migration, invasion | ZEB1 | [204] |