Table 2.
Genotypic distribution of single nucleotide polymorphisms of carbonic anhydrase 9 gene in patients with invasive cancer or preinvasive lesions of uterine cervix and normal women.
| Variables | Controls (n=324) |
Preinvasive lesions (n=88) | Invasive cancer (n=97) | p value | OR (95% CI)b | OR (95% CI)c | AOR (95% CI)d |
|---|---|---|---|---|---|---|---|
| rs2071676 | |||||||
| Co-dominant | 0.068 | ||||||
| GGe | 79 | 18 | 23 | 1.00 | 1.00 | 1.00 | |
| GA | 168 | 54 | 41 | 1.41 (0.78- 2.56) | 0.84 (0.47-1.49) | 0.65 (0.34-1.26) | |
| AA | 77 | 16 | 33 | 0.91 (0.43-1.92) | 1.47 (0.79-2.73) | 1.22 (0.61-2.48) | |
| Dominant | 0.743 | ||||||
| GGe | 79 | 18 | 23 | 1.00 | 1.00 | 1.00 | |
| GA/AA | 245 | 70 | 74 | 1.26 (0.70-2.23) | 1.04 (0.61-1.77) | 0.82 (0.45-1.51) | |
| Recessive | 0.035a | ||||||
| GG/GAe | 247 | 72 | 64 | 1.00 | 1.00 | 1.00 | |
| AA | 77 | 16 | 33 | 0.71 (0.39-1.30) | 1.65 (1.01-2.70) | 1.63 (0.94-2.87) | |
| rs3829078 | |||||||
| Co-dominant | 0.939 | ||||||
| AAe | 294 | 79 | 89 | 1.00 | 1.00 | 1.00 | |
| AG | 29 | 9 | 8 | 1.16 (0.53-2.54) | 0.91 (0.40-2.07) | 0.97 (0.38-2.45) | |
| GG | 1 | 0 | 0 | u.a. | u.a. | u.a. | |
| Dominant | 0.897 | ||||||
| AAe | 294 | 79 | 89 | 1.00 | 1.00 | 1.00 | |
| AG/GG | 30 | 9 | 8 | 1.12 (0.51-2.45) | 0.88 (0.39-1.99) | 0.91 (0.36-2.31) | |
| Recessive AA/AGe |
323 | 88 | 97 | 0.751 | 1.00 | 1.00 | 1.00 |
| GG | 1 | 0 | 0 | u.a | u.a | u.a | |
| rs1048638 | |||||||
| Co-dominant | 0.024a | ||||||
| CCe | 289 | 76 | 75 | 1.00 | 1.00 | 1.00 | |
| CA | 33 | 12 | 22 | 1.38 (0.68-2.81) | 2.57 (1.42-4.66) | 2.23 (1.13-4.39) | |
| AA | 2 | 0 | 0 | u.a. | u.a. | u.a. | |
| Dominant | 0.011a | ||||||
| CCe | 289 | 76 | 75 | 1.00 | 1.00 | 1.00 | |
| CA/AA | 35 | 12 | 22 | 1.30 (0.65-2.63) | 2.42 (1.34-4.37) | 2.15 (1.09-4.20) | |
| Recessive | 0.564 | ||||||
| CC/CAe | 322 | 88 | 97 | 1.00 | 1.00 | 1.00 | |
| AA | 2 | 0 | 0 | u.a. | u.a. | u.a. | |
| 376deletion393 | |||||||
| Ins/inse | 246 | 70 | 74 | 0.355 | 1.00 | 1.00 | 1.00 |
| Ins/del | 76 | 16 | 23 | 0.74 (0.41-1.35) | 1.01 (0.59-1.72) | 1.00 (0.54-1.86) | |
| Del/del | 2 | 2 | 0 | 3.51 (0.49-25. 40) | u.a. | u.a. | |
| Ins/inse | 246 | 70 | 74 | 0.774 | 1.00 | 1.00 | 1.00 |
| Ins/del or del/del | 78 | 18 | 23 | 0.81 (0.46-1.45) | 0.98 (0.58- 1.67) | 0.98 (0.53-1.81) | |
| Ins/ins or ins/dele | 322 | 86 | 97 | 0.184 | 1.00 | 1.00 | 1.00 |
| Del/del | 2 | 2 | 0 | 3.75 (0.52-27.03) | u.a. | u.a. |
Statistical analysis: multiple logistic regression or chi-square or Fisher's exact tests, ap < 0.05. bComparison between patients with cervical preinvasive squamous lesions and control women. cComparison between patients with cervical invasive squamous cell carcinoma and control women. dThe adjusted odds ratio with its 95% CI was estimated by multiple logistic regression models after controlling for age between cancer patients and control women. eUsed as references for comparison to evaluate the odds ratios of other genotypes. AOR, adjusted odds ratio; 95% CI, 95% confidence interval. Del, deletion; ins, insertion; u.a., unavailable.