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. 2018 Apr 3;15(6):628–637. doi: 10.7150/ijms.22723

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Serial cryosections of the gastrocnemius muscle of mice fed normal and resveratrol diets. Atrogin-1 immunoreactivity was visualized using FITC-conjugated antibody. In non-operated gastrocnemius muscle of both diets, immunofluorescence labeling showed that p62/SQSTM1 was not present in the any cytosol of muscle fibers (a-d). Marked increases of p62/SQSTM1 immunoreactivity were observed in the cytosol of several muscle fibers of denervated gastrocnemius of both mice (e-h). Densitometric analysis showed significant increasee in p62/SQSTM1 immunoreactivity in the denervated muscle of mice fed between normal and resveratrol diets (i). However, the percentage of p62/SQSTM1-potitive muscle fibers was significantly lower in the mice fed the resveratrol diet than those of normal one (i). White circles and squares indicate the same fibers on different immunoimages. White arrows denote the p62/SQSTM1-positive muscle fiber. Bar = 50 μm. †† : p < 0.01 compared with the non-operated muscle. **: p < 0.01 compared with normal diet.

Serial cryosections of the gastrocnemius muscle of mice fed normal and resveratrol diets. Atrogin-1 immunoreactivity was visualized using FITC-conjugated antibody. In non-operated gastrocnemius muscle of both diets, immunofluorescence labeling showed that p62/SQSTM1 was not present in the any cytosol of muscle fibers (a-d). Marked increases of p62/SQSTM1 immunoreactivity were observed in the cytosol of several muscle fibers of denervated gastrocnemius of both mice (e-h). Densitometric analysis showed significant increasee in p62/SQSTM1 immunoreactivity in the denervated muscle of mice fed between normal and resveratrol diets (i). However, the percentage of p62/SQSTM1-potitive muscle fibers was significantly lower in the mice fed the resveratrol diet than those of normal one (i). White circles and squares indicate the same fibers on different immunoimages. White arrows denote the p62/SQSTM1-positive muscle fiber. Bar = 50 μm. †† : p < 0.01 compared with the non-operated muscle. **: p < 0.01 compared with normal diet.