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Gene functional annotation and heatmap of pairwise correlations between Wt and Hm. (A, B and C), Gene Set Enrichment analysis indicated that gene sets associated with heart failure are up-regulated at all three ages; (D), A cluster of differentially expressed gene between Wt and Hm at three ages; (E), Molecular function of differentially expressed genes with Gene Ontology (GO) analysis. D, day; Wt, wild type; Hm, homozygous Rbm20 knockout; GO, Gene Ontology.
