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. 2018 Mar 10;14(4):418–426. doi: 10.7150/ijbs.23602

Figure 5.

Figure 5

GLA inhibits the PI3K/Akt pathway in UMUC3 cells. (A, B) UMUC3 cells were treated with GLA (0, 20 and 40 μM) for 24 h. Proteins were extracted and western blotting was then performed to analyze the expressions of PI3K p85, PTEN, Akt, p-Akt (Ser473) are expressed as the mean ± S.D. from three independent experiments. *P < 0.05 vs. the control group. (C) Scheme of the proposed mechanism for GLA-induced G2/M arrest and apoptosis in UMUC3 cells. Red arrows represent inhibition of the next signal while green arrows represent the promotion of the next signal.