Table 1.
Antifungals resistance of Candida isolates from HC or RTT patients
| Species | Antifungals | Healthy controls (HC) | Rett syndrome (RTT) subjects | ||||||
|---|---|---|---|---|---|---|---|---|---|
| MIC (μg/ml) | aCBPs | MIC (μg/ml) | aCBPs | ||||||
| MIC50 | MIC90 | %S | %R | MIC50 | MIC90 | %S | %R | ||
| C. albicans | Fluconazole | 0.5 | > 64 | 75.6 | 24.4 | 1 | 2 | 75 | 25 |
| Itraconazole | 0.25 | > 8 | 36.6 | 63.4 | 0.0156 | 0.0156 | 100 | 0 | |
| 5-Flucytosine | 0.125 | 0.5 | 97.6 | 2.4 | 0.125 | 0.125 | 100 | 0 | |
| C. parapsilosis | Fluconazole | 0.5 | 2 | 92.9 | 7.1 | 2 | > 64 | 64.3 | 35.7 |
| Itraconazole | 0.0156 | 0.125 | 100 | 0 | 0.0156 | > 8 | 64.3 | 35.7 | |
| 5-Flucytosine | 0.125 | 0.5 | 100 | 0 | 0.125 | 0.125 | 100 | 0 | |
| b Candida spp. | Fluconazole | 0.125 | 0.25 | 100 | 0 | > 64 | > 64 | 0 | 100 |
| Itraconazole | 0.0156 | 0.0156 | 100 | 0 | 8 | 8 | 0 | 100 | |
| 5-Flucytosine | 0.125 | 0.125 | 100 | 0 | 0.125 | 0.125 | 100 | 0 | |
aAccording to EUCAST recommendations; S sensible; R Resistant; MIC ranges: Fluconazole 0.125–64 μg/ml; Itraconazole 0.0156–8 μg/ml; 5-Flucytosine 0.125–64 μg/ml. bCandida spp. isolated from RTT subjects (i.e. C. glabrata, C. pararugosa and C. tropicalis); Candida spp. isolated from HC (i.e. C. deformans, C. intermedia and C. lusitaniae)