. 2018 May 2;7:10. doi: 10.1186/s40164-018-0102-0

Table 2.

Association between the expression of miR-130b/301b and putative direct target genes in TCGA-PRAD

Gene	PMID	Role in PrCa	miR-130b		miR-301b
Gene	PMID	Role in PrCa	r	p value	r	p value
PPARGC1A	23868745	TSG? (PMC4884178)	− 0.3571	< 0.0001	− 0.3109	< 0.0001
TP63 ^a	24398967	TSG	− 0.3313	< 0.0001	− 0.2286	< 0.0001
NDRG2 ^b	27327120	TSG	− 0.2985	< 0.0001	− 0.2427	< 0.0001
SLC8A1 ^c	26489476	TSG	− 0.2884	< 0.0001	− 0.3174	< 0.0001
PARVA ^c	26489476	TSG	− 0.2846	< 0.0001	− 0.3113	< 0.0001
SMAD4	24220575	TSG	− 0.2240	< 0.0001	− 0.2151	0.0002
ZBTB4	24220575	TSG	− 0.2231	< 0.0001	− 0.2829	< 0.0001
ITGB1	24498407	TSG	− 0.2119	< 0.0001	− 0.1995	0.0006
STAT3	24040078	OG	− 0.1423	0.0009	− 0.2049	0.0004
ZEB1	22847613	OG	− 0.1338	0.0018	− 0.2058	0.0004
FMR1	24021279	unknown	− 0.1250	0.0035	− 0.1380	0.0175
CSF1	22005523	OG	− 0.1190	0.0055	− 0.1904	0.001
PTEN	24220575	TSG	− 0.1174	0.0062	− 0.1072	0.0654
MMP2^b	25154741	OG	− 0.1094	0.0108	− 0.1286	0.027
PPARG	21135128	TSG	− 0.1072	0.0125	− 0.0358	0.5397
PDGFRA	22995917	OG	− 0.1041	0.0152	− 0.1640	0.0047
UVRAG	22228303	TSG	− 0.0812	0.0585	− 0.0984	0.0909
RUNX3	20176475	TSG	− 0.0220	0.6099	− 0.1161	0.046
AR^b	28192399	TSG	− 0.0201	0.6405	− 0.0772	0.1856
DEDD2^b	27307749	TSG	0.0080	0.8522	0.0418	0.4733
DICER1	23392577	unknown	0.1111	0.0096	0.0297	0.6112
TP53INP1	18974142	OG	0.2378	< 0.0001	0.1746	0.0026
LMNB1 ^b	28166834	OG	0.2404	< 0.0001	0.2071	0.0003
CCNA2	24681352	OG	0.2947	< 0.0001	0.2004	0.0005

Correlation between miRNAs and validated mRNA targets gene expression. For each target gene the role in PrCa, the literature reference (PMID) and the correlation r and p value are shown

Qualifiers in column 1 indicate: ^amiR-301b direct target with strong experimental evidence assigned by TarBase. DNMT1 was listed by TarBase but not included in this list since the referenced article demonstrates the absence of effect of miR-301b on DNMT1

^bDirect target genes with experimental validation in PrCa

^cDirect Targets predicted in PrCa. Absence of qualifier in column one indicates directed targets with strong experimental evidence assigned. TarBase does not identify targets for miR-130b/301b in PrCa. Correlations with p < 0.0001 are highlighted in italics