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. 2018 May 2;19:318. doi: 10.1186/s12864-018-4713-y

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Schematic representation of various mutations generated by CLICK. Two gRNAs and Cas9 formed double-strand breaks (DSB) on each targeted site or a large deletion between the two sites. DSBs repaired by NHEJ caused indel mutations or LD. DSBs elicited a single loxP insertion or floxed allele by HDR repair